Over the course of the past ten years, it has become clear that the gut microbiota has a significant impact on a variety of processes, including the elimination of toxins, the regulation of gut endocrine function and neurological signaling, the modulation of drug action and metabolism, the modulation of host immunity, the digestion of food, and the production of numerous compounds that have an impact on the host. It is now widely acknowledged that the gut microbiome has significant effects on human health. However, only recently has its significance in healthy aging been recognized. A recent study, which was published in Nature Metabolism, looked at the patterns of the gut microbiome in 9000 people between the ages of 18 and 101. It found that microbiome health reflects healthy aging and can predict human survival.The data showed that as people got older, their gut microbiomes became more unique–that is, they became more different from those of other people–starting in middle to late adulthood. This was in line with a steady decline in the number of core bacterial genera, like Bacteroides, which are usually common to humans.Healthy people continued to exhibit an increasingly distinct gut microbial composition as they got older, whereas people in poorer health did not exhibit this pattern.During a 4-year follow-up, survival was significantly reduced in people over 85 with high relative Bacteroides abundance retention and a low gut microbiome uniqueness measure.
Studies on H2 supplements and the gut microbiome may benefit from H2 supplements, according to preliminary findings. They discovered that oral gavage with hydrogen water significantly improved gastrointestinal tract functions and epithelial integrity after irradiating the abdomen, protecting mice from radiation-induced toxicity. According to the findings provided by the researchers, hydrogen water accomplishes this by raising the level of a microRNA in the mouse small intestine and suppressing the expression of MyD88 (myeloid differentiation primary response gene 88, a crucial modulator of the innate immune response to microbial pathogens). Importantly, the composition of the intestinal bacteria remained after irradiation thanks to the hydrogen-water treatment. The effects of H2 supplements on the intestinal environment, including microbial composition and short-chain fatty acids, were the focus of another 2018 study where H2 supplements life extension tablets or regular water was given to the mice here for four weeks. Twenty taxa were found to have significantly different relative abundances in H2 supplement-treated mice. The fact that they are all linked to cholesterol metabolism and liver health raises the possibility that oral intake of the life extension tablets has beneficial effects on the microbiome, despite the fact that the precise function of each of these species has yet to be determined.
The beneficial effects of our life extension tablets on the microbiome have also been demonstrated in other studies on rats, piglets, and mice. Intriguingly, a 2019 study in a rat Parkinson’s disease model demonstrated that treatment with electrolyzed hydrogen-rich water protected against permethrin (PERM), a pesticide used to induce Parkinson’s disease in animal models. Blautia, the Lachnospiraceae family, the Ruminococcaceae family, Papillibacter, Roseburia, Intestinimonas, and Shuttleworthia were among the butyrate-producing bacteria that increased in abundance as a result of the treatment. Butyrate administration has been shown to improve motor deficits, reduce inflammation, and remedy dopamine deficiency in Parkinson’s disease animal models. As a result, hydrogen water appears to be a promising approach for further investigation given the growing body of evidence suggesting that the disease may have its origins in the digestive system.
Another new twofold visually impaired, randomized preliminary surveyed the impacts of ingestion of hydrogen-rich tablets created by means of electrolysis on stool consistency and stomach microbiota in sound people who are not exposed to extreme oxidative pressure because of variables like unreasonable activity. For two weeks, the participants consumed 2 hydrogen tablets or purified tap water each day. In the H2 supplement group, the relative abundance of the Bifidobacterium genus significantly increased. Bifidobacterium longum and Bifidobacterium adolescentis both showed significant increases among Bifidobacterium. In addition, the H2 supplement group’s stool consistency significantly converged with Type 4 (normal) of the Bristol Stool Scale (BSS). The composition of the gut microbiota was altered and stool consistency was normalized when humans ingested tablets containing Bifidobacterium, as has been previously reported to have a clear relationship with stool consistency.
Despite the fact that COVID-19 is primarily a respiratory infection, there is increasing evidence that the gastrointestinal tract may be involved. A recent study found that the composition of the gut microbiome in people with COVID-19 was significantly different from that of people without the virus. Importantly, this distinction was evident regardless of whether the patients had taken any medication. Several gut commensals with known immunomodulatory potential, including Eubacterium rectal, Faecalibacterium prausnitzii, and bifidobacteria, were underrepresented in COVID-19 patients and remained low in samples collected up to 30 days after disease resolution. In addition, the severity of the disease, levels of inflammatory cytokines, and blood markers of tissue damage were all correlated with this altered composition. This suggests that the gut microbiome may have influenced the severity of the disease by influencing the immune response of the host. Based on the fact that hydrogen water improves the microbiome in the gut, it could be used as a therapeutic strategy for COVID-19 patients; however, this is just speculation and would require direct and substantial evidence to support its use.
In conclusion, the microbiome is crucial to human health, and research suggests that a more diverse microbiome is beneficial. From pre-clinical and clinical studies, there is preliminary evidence that H2 supplements life extension tablets may have a positive effect on the gut microbiome, including increasing its diversity. Additionally, more robust clinical trials will further clarify this exciting direction.
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One Response
An interesting discussion is definitely worth comment. I do believe that you should publish more about this subject, it may not be a taboo matter but typically people dont discuss these subjects. To the next! Many thanks!!